Non-coding RNA profile for natural killer cell activity

Natural killer cells (NK cells) are a type of cytotoxic lymphocytes which are involved in innate immunity, alongside with assisting with adaptive immune response. Since they have cytotoxic effects, disruptions in their functionality and development leads to a variety of conditions, whether malignant or non-malignant. The profile and interaction of these non-coding RNAs and NK cells in different conditions is extensively studied, and it is now approved that if dysregulated, non-coding RNAs have detrimental effects on NK cell activity and can contribute to the pathogenesis of diverse disorders. In this review, we aim at a thorough inspection on the role of different non-coding RNAs on the activity and development of NK cells, in a broad spectrum of conditions, including blood-related disorders, viral infections, neurological diseases, gastrointestinal disorders, lung disorders, reproductive system conditions and other types of maladies, alongside with providing insight to the future non-coding RNA-NK cell studies. •Natural killer cells (NK) are cytotoxic immune cells that actively counteract effects of stressed cells like viral infected cells or cancer cells.•Several non-coding RNAs that affect the activity of NK cells have been found to influence survival time of patients with malignancies.•Interactions with non-coding RNAs are critical and any disruptions in these interactions could have adverse effects.