Association of Urinary Sodium Excretion with Vascular Damage: A Local Kidney Effect, Rather Than a Marker of Generalized Vascular Impairment

Evidence suggests that increased salt consumption induces blood pressure- (BP) mediated organ damage, yet it remains unclear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. We studied 197 newly diagnosed and never-treated individuals with hypertension, inter...

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Veröffentlicht in:International journal of hypertension 2018-01, Vol.2018 (2018), p.1-7
Hauptverfasser: Douma, Stella, Aslanidis, Spyros, Gkolias, Vasileios, Vamvakis, Anastasios, Zabulis, Xenophon, Gkaliagkousi, Eugene, Anyfanti, Panagiota, Triantafyllou, Areti, Petidis, Konstantinos
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Sprache:eng
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Zusammenfassung:Evidence suggests that increased salt consumption induces blood pressure- (BP) mediated organ damage, yet it remains unclear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. We studied 197 newly diagnosed and never-treated individuals with hypertension, intermediate hypertensive phenotypes, and normal BP, classified by use of 24-hour ambulatory BP monitoring. Sodium excretion and microalbuminuria were estimated in 24-hour urine samples, dermal capillary density was estimated from capillaroscopy, and arterial stiffness was estimated with pulse wave velocity (PWV) and augmentation index (AIx). Sodium excretion correlated with microalbuminuria (p
ISSN:2090-0384
2090-0392
2090-0392
DOI:10.1155/2018/7620563