Association between lumican gene-1554 T/C polymorphism and high myopia in Asian population:a meta-analysis

AIM:To investigate the association between lumican gene-1554 T/C polymorphism and high myopia susceptibility.METHODS:We searched the published literature in the Medline,Embase,and CBM databases from inception to July 2013.A meta-analysis was performed by the programs RevMan 5.1 and Stata 12.0,and the odds ratio(OR) with 95% confidence interval(CI) was calculated in fixed or random effect model based on heterogeneity test among studies.RESLUTS:Seven case-control studies with a total of 1 233 cases and 936 controls were included.A statistical significant association with high myopia was observed in the recessive model(TT vs CT +CC:OR=1.92;95% CI=1.14-3.23) and codominant model(TT vs CT:OR=1.81,95%CI=1.19-2.75).CONCLUSION:The present meta-analysis suggested that lumican-1554 T/C polymorphism might be moderately associated with high myopia susceptibility.This conclusion warrants confirmation by further studies.