Enhancing Gelatine Hydrogel Robustness with Sacran-Aldehyde: A Natural Cross-Linker Approach

Tunable hydrogels have gained significant attention in the bioengineering field due to their designer preparation approach. Towards this end, gelatine stands out as a promising candidate owing to its desirable attributes, such as biocompatibility, ability to support cell adhesion and proliferation,...

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Veröffentlicht in:Polysaccharides 2024-08, Vol.5 (3), p.320-331
Hauptverfasser: Singh, Maninder, Debas, Alisha, Joshi, Gargi, Okajima, Maiko Kaneko, Rajan, Robin, Matsumura, Kazuaki, Kaneko, Tatsuo
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Sprache:eng
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Zusammenfassung:Tunable hydrogels have gained significant attention in the bioengineering field due to their designer preparation approach. Towards this end, gelatine stands out as a promising candidate owing to its desirable attributes, such as biocompatibility, ability to support cell adhesion and proliferation, biodegradability, and cost-effectiveness. This study presents the preparation of a robust gelatine hydrogel employing sacran aldehyde (SDA) as a natural cross-linker. The resulting SDA-cross-linked gelatine hydrogels (GSDA) display an optimal compressive stress of 0.15 MPa at 50% strain, five times higher than pure gelatine hydrogel. As SDA cross-linking concentration is increased, the swelling capacity of GSDA declines. This decline in swelling capacity, from 80% to 40%, is a result of strong crosslinking of gelatin with SDA. Probing further with FT-IR spectroscopy and SEM at the micron scale unveiled a dual-cross-linking mechanism within the hydrogels. This mechanism encompasses both short- and long-range covalent cross-linking, along with thermo-induced physical cross-linking, resulting in a significant enhancement of the load-bearing capacity of the fabricated hydrogels.
ISSN:2673-4176
2673-4176
DOI:10.3390/polysaccharides5030021