Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase

The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focu...

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Veröffentlicht in:	Clinical and molecular hepatology 2015-12, Vol.21 (4), p.319-325
1. Verfasser:	Iwakiri, Yasuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biology Biosynthesis Cytokines Endothelial Cells - metabolism Enzymes Extracellular matrix Growth factors Hepatic stellate cell Hepatic Stellate Cells - metabolism Homeostasis Humans iNOS Kinases Kupffer cell Kupffer Cells - metabolism Liver cirrhosis Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Liver sinusoidal endothelial cell Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - antagonists & inhibitors Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Pathophysiology Polymorphism, Single Nucleotide Proteins Review RNA, Untranslated - metabolism Roles Transcription factors
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Beschreibung
Zusammenfassung:	The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.
ISSN:	2287-2728 2287-285X
DOI:	10.3350/cmh.2015.21.4.319