A short discussion about the SARS-CoV-2 mRNA-1273 vaccine

•SARS-CoV-2 vaccines must balance efficacy with speed of development.•Vaccines should aim to also establish cellular T-cell immunity.•We encourage industry to publish parameters related to cellular immunity.•Discussion of vaccine candidates from Moderna, Pfizer and BioNtech. The COVID-19 global pand...

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Veröffentlicht in:International journal of infectious diseases 2021-03, Vol.104, p.532-533
Hauptverfasser: Oronsky, Bryan, Gruber, Harry E., Reiners, Wendy, Reid, Tony R.
Format: Artikel
Sprache:eng
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Zusammenfassung:•SARS-CoV-2 vaccines must balance efficacy with speed of development.•Vaccines should aim to also establish cellular T-cell immunity.•We encourage industry to publish parameters related to cellular immunity.•Discussion of vaccine candidates from Moderna, Pfizer and BioNtech. The COVID-19 global pandemic has prompted accelerated vaccine development efforts. This perspective discusses the importance of SARS-CoV-2 vaccine candidates’ recruitment of cellular T-cell immunity and encourages industry to increasingly investigate and publish parameters related to cellular immunity in their research reports.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2021.01.048