Detection of MET Alterations Using Cell Free DNA and Circulating Tumor Cells from Cancer Patients

MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed amplificat...

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Veröffentlicht in:	Cells (Basel, Switzerland) Switzerland), 2020-02, Vol.9 (2), p.522
Hauptverfasser:	Mondelo-Macía, Patricia, Rodríguez-López, Carmela, Valiña, Laura, Aguín, Santiago, León-Mateos, Luis, García-González, Jorge, Abalo, Alicia, Rapado-González, Oscar, Suárez-Cunqueiro, Mercedes, Díaz-Lagares, Angel, Curiel, Teresa, Calabuig-Fariñas, Silvia, Azkárate, Aitor, Obrador-Hevia, Antònia, Abdulkader, Ihab, Muinelo-Romay, Laura, Diaz-Peña, Roberto, López-López, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomarkers Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Biopsy Cancer therapies Case-Control Studies Cell growth Cell-Free Nucleic Acids - blood circulating free dna (cfdna) circulating tumor cells (ctcs) Colorectal cancer Copy number Deoxyribonucleic acid DNA Drug Resistance, Neoplasm - genetics Epidermal growth factor receptors ErbB Receptors - antagonists & inhibitors Female Gastric cancer Gene Dosage Growth factors Head & neck cancer Humans Kinases Liquid Biopsy Male Medical prognosis met amplification met copy number met protein expression Metastasis Neoplasms - blood Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Neoplastic Cells, Circulating - metabolism Prospective Studies Prostate Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Proteins Proto-Oncogene Proteins c-met - blood Proto-Oncogene Proteins c-met - genetics Retrospective Studies targeted therapy Tumor cells Tumors
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Zusammenfassung:	MET alterations may provide a potential biomarker to evaluate patients who will benefit from treatment with MET inhibitors. Therefore, the purpose of the present study is to investigate the utility of a liquid biopsy-based strategy to assess MET alterations in cancer patients. We analyzed amplification in circulating free DNA (cfDNA) from 174 patients with cancer and 49 healthy controls and demonstrated the accuracy of the analysis to detect its alteration in patients. Importantly, a significant correlation between cfDNA concentration and copy number (CN) in cancer patients ( = 0.57,
ISSN:	2073-4409 2073-4409
DOI:	10.3390/cells9020522