Histone H3K27M Mutation Overrides Histological Grading in Pediatric Gliomas

Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumor samples...

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Veröffentlicht in:Scientific reports 2020-05, Vol.10 (1), p.8368-8368, Article 8368
Hauptverfasser: Mosaab, Amal, El-Ayadi, Moatasem, Khorshed, Eman N., Amer, Nada, Refaat, Amal, El-Beltagy, Mohamed, Hassan, Zeinab, Soror, Sameh H., Zaghloul, Mohamed Saad, El-Naggar, Shahenda
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Sprache:eng
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Zusammenfassung:Pediatric high-grade gliomas (HGG) are rare aggressive tumors that present a prognostic and therapeutic challenge. Diffuse midline glioma, H3K27M–mutant is a new entity introduced to HGG in the latest WHO classification. In this study we evaluated the presence of H3K27M mutation in 105 tumor samples histologically classified into low-grade gliomas (LGG) (n = 45), and HGG (n = 60). Samples were screened for the mutation in histone H3.3 and H3.1 variants to examine its prevalence, prognostic impact, and assess its potential clinical value in limited resource settings. H3K27M mutation was detected in 28 of 105 (26.7%) samples, and its distribution was significantly associated with midline locations ( p-value  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-65272-x