High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection

The novel WBN/Kob- ( ) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. Howeve...

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Veröffentlicht in:Helminthologia 2018-03, Vol.55 (1), p.12-20
Hauptverfasser: Okamoto, M., Ito, R., Taira, K., Ikeda, T.
Format: Artikel
Sprache:eng
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Zusammenfassung:The novel WBN/Kob- ( ) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. However, inflammatory cytokine profiles and their correlations with T2DM development/progression in rats have not been studied. In this study, we found that the rats had considerably high plasma levels of interleukin (IL)-1α. Abundant cecal IL-1α mRNA expression and cecal inflammation with infiltrating IL-1α-producing macrophages was observed in rats. Bone marrow derived macrophages from rats expressed high levels of IL-1α upon lipopolysaccharide stimulation. Furthermore, infection, which delays the onset of T2DM, reduced both plasma and cecal IL-1α levels in rats. These results suggest that macrophage infiltration and IL-1α secretion comprise an important part of T2DM development and that infection inhibits pro-inflammatory cytokine expression in rats.
ISSN:0440-6605
1336-9083
1336-9083
DOI:10.1515/helm-2017-0050