High IL-1α production was induced in the WBN/Kob-Leprfa type 2 diabetes mellitus rat model and inhibited by Syphacia muris infection
The novel WBN/Kob- ( ) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. Howeve...
Gespeichert in:
Veröffentlicht in: | Helminthologia 2018-03, Vol.55 (1), p.12-20 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | The novel WBN/Kob-
(
) congenic rat strain is considered a useful rat model of type 2 diabetes mellitus (T2DM). Accumulating findings suggest that low-grade inflammation is a causative factor in T2DM and that circulating levels of inflammatory cytokines are associated with insulin resistance. However, inflammatory cytokine profiles and their correlations with T2DM development/progression in
rats have not been studied. In this study, we found that the
rats had considerably high plasma levels of interleukin (IL)-1α. Abundant cecal IL-1α mRNA expression and cecal inflammation with infiltrating IL-1α-producing macrophages was observed in
rats. Bone marrow derived macrophages from
rats expressed high levels of IL-1α upon lipopolysaccharide stimulation. Furthermore,
infection, which delays the onset of T2DM, reduced both plasma and cecal IL-1α levels in
rats. These results suggest that macrophage infiltration and IL-1α secretion comprise an important part of T2DM development and that
infection inhibits pro-inflammatory cytokine expression in
rats. |
---|---|
ISSN: | 0440-6605 1336-9083 1336-9083 |
DOI: | 10.1515/helm-2017-0050 |