Therapeutic targets of hypercholesterolemia: HMGCR and LDLR

Therapeutic targets of hypercholesterolemia: HMGCR and LDLR

Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are m...

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Veröffentlicht in:Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2019-08, Vol.12, p.1543-1553
Hauptverfasser: Ma, Shizhan, Sun, Wenxiu, Gao, Ling, Liu, Shudong
Format: Artikel
Sprache:eng
Schlagworte:
Amino acids
Bile
Bile acids
Cholesterol
Cholesterol homeostasis
CVD
Deoxycholic acid
Diabetes
Enzymes
Health aspects
Heme
HMGCR
Homeostasis
Hormones
Hypercholesterolemia
LDLR
Liver
Low density lipoproteins
Physiological aspects
Review
Steroid hormones
Thiols
Type 2 diabetes
Vitamin D
Vitamins
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Zusammenfassung:Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis. We summarize the regulatory mechanisms of HMGCR and LDLR, which may provide insight for new drug design and development. Keywords: cholesterol homeostasis, CVD, HMGCR, LDLR
ISSN:1178-7007
1178-7007
DOI:10.2147/DMSO.S219013