A microbiota‐based predictive model for type 2 diabetes remission induced by dietary intervention: From the CORDIOPREV study

[...]the normalization of plasma glucose levels can occur in some patients just days after bariatric surgical intervention, and even before achieving significant weight loss.2 This observation points to a relevant glucoregulatory role of the gastrointestinal tract. [...]microbiome biomarkers could potentially be used to identify subjects who might benefit from specific dietary interventions.11 Our study, conducted in 110 newly diagnosed type 2 diabetes patients with coronary heart disease (CHD) within the Coronary Diet Intervention with Olive Oil and Cardiovascular Prevention (CORDIOPREV) study, evaluated whether baseline gut microbiota composition, in addition to the classic type 2 diabetes risk-associated variables, improves the identification of patients who underwent type 2 diabetes remission achieved by two dietary models (low-fat or Mediterranean diet) after a 5-year follow-up (responders, n = 44) and those who did not respond to the dietary intervention (nonresponders, n = 66), with both groups presenting the same adherence to both diets, and without promoting changes in lifestyle such as weight loss or medication. TABLE 1 Baseline characteristics of the newly diagnosed type 2 diabetes population for type 2 diabetes mellitus remission study and of the population with analyzed gut microbiota Responders Nonresponders Responders† Nonresponders† (n = 73) (n = 110) p value (n = 44) (n = 66) p value Men/women 60/13 92/18 0.799 36/8 56/10 0.674 Age (years) 60.8 ± 1.0 59.3 ± 0.9 0.252 60.1 ± 1.3 57.7 ± 1.2 0.198 Weight (kg) 80.2 ± 1.3 88.4 ± 1.4