Long-Term Experience of a Reference Center on Autosomal Dominant Polycystic Kidney Disease: Associated Demographics, Clinical Presentation, and Kidney Survival in Turkish Population

Objective: The autosomal dominant polycystic kidney disease is the most common genetic cause of chronic kidney disease. In this context, it was aimed to investigate the demographical, clinical, and laboratory findings of, and the treatment methods implemented on, patients with autosomal dominant polycystic kidney disease, along with the factors that can be associated with kidney survival. Methods: Hospital records of autosomal dominant polycystic kidney disease patients, who were followed up by our nephrology clinic, were analyzed retrospectively. Demographical, clinical, and laboratory findings, treatments, and kidney survival of patients were recorded. Kidney survival of patients who were either lost to follow-up or followed by another center was learned through phone calls. Results: The data of 300 patients with a diagnosis of autosomal dominant polycystic kidney disease, 157 of whom were women and 143 men of whom were men, were analyzed within the scope of the study. Been diagnosed at a younger age, female gender, having a high estimated glomerular filtration rate at initial admission, and use of renin-angiotensin system blockers were determined to be significant in better kidney survival. Moreover, the use of renin-angiotensin system blockers was also determined to be significant for longer kidney survival in patients with less than 1 g/day proteinuria. Conclusion: It was concluded as a result of the study that early diagnosis and treatment management of autosomal dominant polycystic kidney disease patients are of paramount importance. Additionally, the results of the study suggest that the use of renin-angiotensin system blockers in hypertensive patients with autosomal dominant polycystic kidney disease may be a factor for better kidney survival. Keywords: Autosomal dominant polycystic kidney disease, hypertension, renin-angiotensin system