Exploring the relationship between condition severity and health-related quality of life in people with haemophilia A across Europe: a multivariable analysis of data from the CHESS II study

Haemophilia A (HA; Factor VIII deficiency) is a congenital X-linked bleeding disorder characterized by trauma-related or spontaneous bleeding events, most notably arising within the intraarticular space and resulting in chronic inflammation and degeneration of affected joints. Endogenous clotting fa...

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Veröffentlicht in:	Health and quality of life outcomes 2024-07, Vol.22 (1), p.58-9, Article 58
Hauptverfasser:	Ferri Grazzi, Enrico, Hawes, Charles, Camp, Charlotte, Hinds, David, O'Hara, Jamie, Burke, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Activities of daily living Adolescent Adult Adults Aged Analgesics Annual bleeding rate Bleeding Body mass index Body size Care and treatment Chronic pain Clinical outcomes Clotting Coagulation factors Cross-Sectional Studies Data capture Data collection Degeneration Disease prevention Europe Factor VIII deficiency Female Haemophilia A Health aspects Health-related quality of life Hemophilia Hemophilia A - complications Hemophilia A - psychology Humans Hypotheses Inflammation Joint diseases Male Marital status Middle Aged Multivariate Analysis Narcotics Pain Patient-reported outcomes Patients Problem joints Prognosis Quality of life Quality of Life - psychology Regression analysis Regression models Retrospective Studies Severity of Illness Index Surveys and Questionnaires Young Adult
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Beschreibung
Zusammenfassung:	Haemophilia A (HA; Factor VIII deficiency) is a congenital X-linked bleeding disorder characterized by trauma-related or spontaneous bleeding events, most notably arising within the intraarticular space and resulting in chronic inflammation and degeneration of affected joints. Endogenous clotting factor activity relative to normal levels determines the severity of HA symptoms, as mild (> 5-40%), moderate (1-5%), or severe (
ISSN:	1477-7525 1477-7525
DOI:	10.1186/s12955-024-02267-6