Simultaneous Amelioratation of Colitis and Liver Injury in Mice by Bifidobacterium longum LC67 and Lactobacillus plantarum LC27

Disturbances in the gut microbiota composition are associated with chronic inflammatory diseases of the intestine and the liver. In a preliminary study, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 could inhibit Escherichia coli growth and lipopolysaccharide-induced NF-κB activation...

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Veröffentlicht in:	Scientific reports 2018-05, Vol.8 (1), p.7500-14, Article 7500
Hauptverfasser:	Jang, Se-Eun, Jeong, Jin-Ju, Kim, Jeon-Kyung, Han, Myung Joo, Kim, Dong-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/21 13/31 38/22 38/77 631/250/347 631/326/1320 64/60 Alanine Alanine transaminase Aspartate transaminase Bifidobacterium longum Blood Colitis Colon Digestive system E coli Gastrointestinal tract Helper cells Humanities and Social Sciences Inflammatory bowel disease Inflammatory diseases Intestinal microflora Intestine Lactobacillus plantarum Lipopolysaccharides Liver Lymphocytes T Microbiota multidisciplinary NF-κB protein Oral administration Peroxidase Probiotics Rodents Science Science (multidisciplinary) t-Butylhydroperoxide Transaminase
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Zusammenfassung:	Disturbances in the gut microbiota composition are associated with chronic inflammatory diseases of the intestine and the liver. In a preliminary study, Lactobacillus plantarum LC27 and Bifidobacterium longum LC67 could inhibit Escherichia coli growth and lipopolysaccharide-induced NF-κB activation linked to gut inflammation. Here, we investigated their effects on 2,4,6-trinitrobenzesulfonic acid (TNBS)-induced colitis and liver damage in mice. First, oral administration of LC27 or LC67 (1 × 10 9 CFU/mouse) inhibited TNBS-induced colon shortening [F(5,30) = 100.66, P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-018-25775-0