Editorial: Neuroepigenetics and biological mechanisms of stress-induced socio-cognitive changes

[...]gaining insights into the overarching macro (between brain regions) and microcircuitry (within a brain region), along with the molecular mechanisms, provides a promising platform to effectively address fear-related disorders. A rodent-based study investigating the role of cytokines in this regard, provides some insight into this matter (Xia et al.). [...]a study by Zhang et al. underscores that prenatal exposure to inflammation heightens the risk of offspring to neuropsychiatric disorders such as anxiety, depression, and cognitive dysfunction, while maternal sleep deprivation during pregnancy exacerbates these outcomes. Additionally, it addresses the escalating global concern of substance abuse and the incomplete understanding of the pathophysiology of SUD, underscoring the potential insights gained through preclinical study that focus on alterations in gene expression.