In Utero Particulate Matter Exposure Produces Heart Failure, Electrical Remodeling, and Epigenetic Changes at Adulthood

Particulate matter (PM; PM [PM with diameters of

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American Heart Association 2017-04, Vol.6 (4)
Hauptverfasser:	Tanwar, Vineeta, Gorr, Matthew W, Velten, Markus, Eichenseer, Clayton M, Long, 3rd, Victor P, Bonilla, Ingrid M, Shettigar, Vikram, Ziolo, Mark T, Davis, Jonathan P, Baine, Stephen H, Carnes, Cynthia A, Wold, Loren E
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Age Factors air pollution Animals Animals, Newborn Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - metabolism Arrhythmias, Cardiac - physiopathology Atrial Remodeling - drug effects calcium signaling Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Calcium-Transporting ATPases - genetics Calcium-Transporting ATPases - metabolism cardiac cardiovascular function DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Methyltransferase 3A DNA Methyltransferase 3B Epigenesis, Genetic - drug effects Female Gestational Age heart failure Heart Failure - chemically induced Heart Failure - genetics Heart Failure - metabolism Heart Failure - physiopathology Heart Rate - drug effects in utero Inhalation Exposure - adverse effects Maternal Exposure - adverse effects Mice Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Original Research Particle Size Particulate Matter - toxicity Phosphorylation Pregnancy Prenatal Exposure Delayed Effects Sirtuin 1 - genetics Sirtuin 1 - metabolism Sirtuin 2 - genetics Sirtuin 2 - metabolism Sodium-Calcium Exchanger - genetics Sodium-Calcium Exchanger - metabolism Ventricular Function, Left - drug effects Ventricular Remodeling - drug effects
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Beschreibung
Zusammenfassung:	Particulate matter (PM; PM [PM with diameters of
ISSN:	2047-9980 2047-9980
DOI:	10.1161/JAHA.117.005796