Cell Composition of Cord Blood and G-Scf-Mobilized Blood Transplantational Material

Cord blood cell composition is a short-lasting delivery stress consequence and is similar on adult G-CSF-mobilized peripheral blood. G-SCF realizes biological effect by number of secondary messengers, many of which are also natural effectors of stress. In this research comparative characteristics of...

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Veröffentlicht in:	Medicinskij vestnik Ûga Rossii 2010-06 (2), p.26-34
Hauptverfasser:	R. Sh. Ibragimov, E. V. Raikina, E. Yu. Osipova, O. A. Maiorova, M. V. Yakovleva, S. A. Roumiantsev
Format:	Artikel
Sprache:	eng
Schlagworte:	cd133+cells cd34+cells cord blood granulocyte colony stimulated factor (g-csf) mobilization
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Zusammenfassung:	Cord blood cell composition is a short-lasting delivery stress consequence and is similar on adult G-CSF-mobilized peripheral blood. G-SCF realizes biological effect by number of secondary messengers, many of which are also natural effectors of stress. In this research comparative characteristics of cell composition, including lymphocytes subpopulations, CD34+ and CD133+ cells, hematopoietic progenitor cells colony-forming activity and mobilizing cytokines concentration (IL-8, MMP-2, MMP-9), between term newborns cord blood and G-SCF-mobilized peripheral blood is shown. Mobilized cytokines concentration ratio in combination with CD34+ cells count in cord blood and mobilized peripheral blood suggests that delivery stress possibly is not single cause of cord blood features.
ISSN:	2219-8075 2618-7876