6p21 translocation renal cell carcinoma: A case report

6p21 translocation renal cell carcinoma: A case report

6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an asymptomatic solid mass in the right kidney identifie...

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Veröffentlicht in:Urology case reports 2021-01, Vol.34, p.101470, Article 101470
Hauptverfasser: Sano, Yuho, Tanimoto, Ryuta, Sasaki, Katsumi, Nakamura, Satoko, Mizobuchi, Koichi, Kuroda, Naoto
Format: Artikel
Sprache:eng
Schlagworte:
6p21 translocation RCC
MIT family Translocation
Oncology
Robotic-assisted partial nephrectomy
TFEB
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Zusammenfassung:6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an asymptomatic solid mass in the right kidney identified during routine medical checkup. Computed tomography (CT) revealed a 14-mm buried-type solid mass accompanied by punctate calcification. CT-guided biopsy suggested clear-cell carcinoma. He underwent robotic-assisted partial nephrectomy. Pathological findings revealed 6p21 translocation RCC based on diffuse nuclear immunoreactivity for TFEB and TFEB gene rearrangement in tumor cells by FISH analysis.
ISSN:2214-4420
2214-4420
DOI:10.1016/j.eucr.2020.101470