Reorganization of gray matter networks in patients with Moyamoya disease

Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were analyzed. C...

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Veröffentlicht in:	Scientific reports 2025-01, Vol.15 (1), p.2788-11
Hauptverfasser:	Zhu, Huan, Wang, Peijiong, Li, Wenjie, Zhang, Qihang, Zhu, Chenyu, Liu, Tong, Yu, Tao, Liu, Xingju, Zhang, Qian, Zhao, Jizong, Zhang, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308 692/617 692/617/375 692/617/375/380 692/699 Adult Asymptomatic Case-Control Studies Cortex (frontal) Cortex (olfactory) Female Frontal gyrus Functional anatomy Globus pallidus Graph theory Gray Matter - diagnostic imaging Gray Matter - pathology Gray Matter Network Gray Matter volume Hemorrhage Humanities and Social Sciences Humans Ischemia Magnetic Resonance Imaging Male Middle Aged Moyamoya Disease Moyamoya Disease - diagnostic imaging Moyamoya Disease - pathology Moyamoya Disease - physiopathology multidisciplinary Nerve Net - diagnostic imaging Nerve Net - pathology Nerve Net - physiopathology Network-based statistic Science Science (multidisciplinary) Structure-function relationships Substantia alba Substantia grisea Topology Young Adult
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Zusammenfassung:	Patients with Moyamoya disease (MMD) exhibit significant alterations in brain structure and function, but knowledge regarding gray matter networks is limited. The study enrolled 136 MMD patients and 99 healthy controls (HCs). Clinical characteristics and gray matter network topology were analyzed. Compared to HCs, MMD patients exhibited decreased clustering coefficient (Cp) ( P = 0.006) and local efficiency (Eloc) ( P = 0.013). Ischemic patients showed decreased Eloc and increased characteristic path length (Lp) compared to asymptomatic and hemorrhagic patients ( P
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-025-86553-3