In vitro anti-Candida activity of certain new 3-(1H-imidazol-1-yl)propan-1-one oxime esters

Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2013-09, Vol.18 (10), p.12208-12221
Hauptverfasser:	Attia, Mohamed I, Zakaria, Azza S, Almutairi, Maha S, Ghoneim, Soraya W
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-Candida Antifungal agents Antifungal Agents - chemical synthesis Antifungal Agents - pharmacology azoles Candida albicans - drug effects Candida tropicalis - drug effects Chemistry Esters Fluconazole - pharmacology Fungal infections Imidazoles - chemical synthesis Imidazoles - pharmacology Mannich reaction Miconazole - pharmacology Microbial Sensitivity Tests oxime esters Oximes - chemical synthesis Oximes - pharmacology Pharmaceuticals Pharmacy synthesis
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Beschreibung
Zusammenfassung:	Anti-Candida activities of certain new oximes 4a-d and their respective aromatic esters 5a-l are reported. The tested compounds 4a-d and 5a-l exhibited better anti-Candida profiles than fluconazole. Compound 5j, namely (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-4-chlorobenzoyl oxime emerged as the most active congener, with a MIC value of 0.0054 µmol/mL being more potent than both fluconazole (MIC > 1.6325 µmol/mL) and miconazole (MIC value = 0.0188 µmol/mL) as a new anti-Candida albicans agent.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules181012208