Metformin-mediated effects on mesenchymal stem cells and mechanisms: proliferation, differentiation and aging
Mesenchymal stem cells (MSCs) are a type of pluripotent adult stem cell with strong self-renewal and multi-differentiation abilities. Their excellent biological traits, minimal immunogenicity, and abundant availability have made them the perfect seed cells for treating a wide range of diseases. Afte...
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Veröffentlicht in: | Frontiers in pharmacology 2024-08, Vol.15, p.1465697 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Mesenchymal stem cells (MSCs) are a type of pluripotent adult stem cell with strong self-renewal and multi-differentiation abilities. Their excellent biological traits, minimal immunogenicity, and abundant availability have made them the perfect seed cells for treating a wide range of diseases. After more than 60 years of clinical practice, metformin is currently one of the most commonly used hypoglycaemic drugs for type 2 diabetes in clinical practice. In addition, metformin has shown great potential in the treatment of various systemic diseases except for type 2 diabetes in recent years, and the mechanisms are involved with antioxidant stress, anti-inflammatory, and induced autophagy, etc. This article reviews the effects and the underlying mechanisms of metformin on the biological properties, including proliferation, multi-differentiation, and aging, of MSCs
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with the aim of providing theoretical support for in-depth scientific research and clinical applications in MSCs-mediated disease treatment. |
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ISSN: | 1663-9812 1663-9812 |
DOI: | 10.3389/fphar.2024.1465697 |