Editorial: Protein Degradation, Aggregation, Membrane Trafficking and Exosomes in Neuronal Health and Disease

Here, Farrell et al., via proteomics and liquid chromatography/mass spectrometry (LC/MS) describe proteasome targets in the amygdala following fear conditioning, and find evidence that these targets can vary depending on the sex. While there can be many reasons for these failures, one could be the failure of several cellular systems interacting together. [...]effective therapies may be needed which target multiple cellular pathways. Another type of vesicle, the extracellular vesicles (EVs) are critical for cell-to-cell communication, their cargo is highly varied including proteins, nucleic acids and mitochondria, Amari and Germain carefully reviewed and discussed recent evidence suggesting that mitochondria transferred through EVs have the capacity to alter metabolic and inflammatory responses in the recipient cells. Besides the capacity of EVs to elicit a response in the target cells, EVs can also accelerate the spreading of protein aggregation, and this capacity is closely related to lipid alterations.