Nitrogenase Fe Protein: A Multi-Tasking Player in Substrate Reduction and Metallocluster Assembly

The Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the biosynthesis of the complex metalloclusters of ni...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (19), p.6743
Hauptverfasser:	Ribbe, Markus W, Górecki, Kamil, Grosch, Mario, Solomon, Joseph B, Quechol, Robert, Liu, Yiling A, Lee, Chi Chung, Hu, Yilin
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Biosynthesis Carbon dioxide Carbon Dioxide - chemistry Catalysis Chelating agents Chemical properties Crystal structure Enzymes Fe protein FeS enzyme Hydrocarbons Iron proteins Iron sulfides Methods Multitasking Nitrogen Nitrogenase Nitrogenase - metabolism Oxidation Oxidation-Reduction Oxidoreductases - metabolism Proteins reductase Reductases Reduction (metal working) Review Signal transduction Substrates
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Beschreibung
Zusammenfassung:	The Fe protein of nitrogenase plays multiple roles in substrate reduction and metallocluster assembly. Best known for its function to transfer electrons to its catalytic partner during nitrogenase catalysis, the Fe protein is also a key player in the biosynthesis of the complex metalloclusters of nitrogenase. In addition, it can function as a reductase on its own and affect the ambient reduction of CO or CO to hydrocarbons. This review will provide an overview of the properties and functions of the Fe protein, highlighting the relevance of this unique FeS enzyme to areas related to the catalysis, biosynthesis, and applications of the fascinating nitrogenase system.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27196743