Features of calcium signaling in ischemic injury nervous tissue – of neurons in the hippocampus

This review describes the features of the systems to ensure the restoration of calcium homeostasis of hippocampal neurons during ischemic injury. High levels of intracellular Ca 2+, glutamate excitotoxicity activity and the formation of free radicals during ischemia are a major damaging factors, lea...

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Veröffentlicht in:	Bulletin of Taras Shevchenko National University of Kyiv. Series, Biology Biology, 2016-07, Vol.70 (2), p.70-73
Hauptverfasser:	Maistrenko, A., Voitenko, N.
Format:	Artikel
Sprache:	eng ; ukr
Schlagworte:	calcium glutamic acid hippocampus homeostasis ischemia SERCA – Ca2+-ATPase of endoplasmic reticulum, PMCA – Ca2+ATP-ASE of plasmatic membrane, ischemic injury, the hippocampus
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Zusammenfassung:	This review describes the features of the systems to ensure the restoration of calcium homeostasis of hippocampal neurons during ischemic injury. High levels of intracellular Ca 2+, glutamate excitotoxicity activity and the formation of free radicals during ischemia are a major damaging factors, leading to further damage to hippocampal neurons. Understanding the mechanisms able to prevent the development of damage today is key for the development of post- and preconditioning neuroprotective strategies.
ISSN:	1728-2748 2308-8036 2308-8036
DOI:	10.17721/1728_2748.2015.70.70-73