Synthesis, in vitro antimycobacterial and antibacterial evaluation of IMB-070593 derivatives containing a substituted benzyloxime moiety

A series of novel IMB-070593 derivatives containing a substituted benzyloxime moiety and displaying a remarkable improvement in lipophilicity were synthesized and evaluated for their in vitro antimycobacterial and antibacterial activity. Our results reveal that the target compounds 19a-m have consid...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2013-03, Vol.18 (4), p.3872-3893
Hauptverfasser:	Wei, Zengquan, Wang, Jian, Liu, Mingliang, Li, Sujie, Sun, Lanying, Guo, Huiyuan, Wang, Bin, Lu, Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - pharmacology antibacterial activity antimycobacterial activity benzyloxime Ciprofloxacin - pharmacology Drug resistance Gram-Negative Bacteria - drug effects IMB-070593 derivatives Levofloxacin Magnetic Resonance Spectroscopy Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Mycobacterium tuberculosis - drug effects Ofloxacin - pharmacology Oximes - pharmacology Piperidines - pharmacology Staphylococcus aureus - drug effects synthesis Toxicity Tuberculosis
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Zusammenfassung:	A series of novel IMB-070593 derivatives containing a substituted benzyloxime moiety and displaying a remarkable improvement in lipophilicity were synthesized and evaluated for their in vitro antimycobacterial and antibacterial activity. Our results reveal that the target compounds 19a-m have considerable Gram-positive activity (MIC:
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules18043872