Clinical characteristics and prognostic importance of anticoagulant use in ischemic left ventricular aneurysm: a retrospective cohort study

There is insufficient data on systemic embolic events (SSEs) in patients with ischemic left ventricular aneurysm (LVA) concerning the impact of anticoagulation therapy. In this retrospective cohort study with 1043 patients with ischemic LVA, SSEs occurred in 7.2% over 2.4 years. After adjusting for...

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Veröffentlicht in:	Nature communications 2024-08, Vol.15 (1), p.6883-10, Article 6883
Hauptverfasser:	Chen, Qin-Fen, Wang, Liangguo, Katsouras, Christos S., Gong, Mengge, Liu, Chenyang, Lian, Liyou, Chen, Xiaoyan, Zhu, Xuemeng, Chen, Chen, Feng, Xiaofang, Lin, Wei-Hong, Zhou, Xiao-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	692/308/409 692/699/75/2/1674 Aged Aneurysm Aneurysms Anticoagulants Anticoagulants - therapeutic use Bleeding Cohort analysis Embolism - drug therapy Embolism - epidemiology Female Health risks Heart Heart Aneurysm - drug therapy Heart Aneurysm - epidemiology Heart Ventricles - drug effects Heart Ventricles - pathology Heart Ventricles - physiopathology Hemorrhage - chemically induced Hemorrhage - epidemiology Humanities and Social Sciences Humans Ischemia Male Middle Aged multidisciplinary Myocardial Ischemia - drug therapy Myocardial Ischemia - epidemiology Prognosis Retrospective Studies Risk Factors Science Science (multidisciplinary) Segments Ventricle
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Zusammenfassung:	There is insufficient data on systemic embolic events (SSEs) in patients with ischemic left ventricular aneurysm (LVA) concerning the impact of anticoagulation therapy. In this retrospective cohort study with 1043 patients with ischemic LVA, SSEs occurred in 7.2% over 2.4 years. After adjusting for relevant factors, the use of anticoagulants was independently associated with a lower incidence of SSE (3.1% vs. 9.0%, P
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-024-51121-2