Effects of Various Direct-acting Antivirals in the Quality of Life of Patients with Chronic Hepatitis C

Introduction: Chronic hepatitis C is an infectious disease known to affect people worldwide. The disease is characterized by both hepatic and extrahepatic manifestations that impair the patient’s overall quality of life (QoL). Potent and easy-to-use direct-acting antivirals (DAAs) have been recently introduced to treat chronic hepatitis C virus (HCV) infection. This study aimed to assess the QoL of patients with chronic HCV before and after DAAs treatment. Materials and Methods: The Liver Disease Symptom Index 2.0, Short Form-36 (SF-36), and Beck-Anxiety Inventory scale were administered before and at the end of the treatment to evaluate the QoL in patients who were initiated with sofosbuvir and ledipasvir (SOF/LED)±ribavirin (RBV) or ombitasvir, paritaprevir, ritonavir, and dasabuvir (PROD). In addition, another questionnaire was used to evaluate the treatment waiting period effects on the patients’ psychology. Results: A total of 46 patients receiving DAAs were included in the study, 22 of which received SOF/LED (group 1), four received SOF/LED+RBV (group 2), and 20 received PROD (group 3). At the end of the treatment, a significant improvement was observed in The Liver Disease Symptom Index 2.0 items including daytime sleepiness, effect of sleepiness on daily life, presence of depression, effect of depression on daily life, and fear of developing liver disease complication (p=0.002, p=0.035, p