Blood coagulation alterations over the first 10 days after severe burn injury

•Modest and self-resolutive coagulation disorders occur during the first 72 h.•The alterations are proportional to fluid resuscitation volume and burn severity indicating a dilution effect.•This study does not confirm any specific burn associated coagulopathy.•A late thrombocytopenia is described. Coagulation disorders occur during the first 48 h after major burn injury, affecting mainly PT/INR and aPTT. Some authors consider them burn specific. The aim was to assess the magnitude of coagulation disorders during the first 10 days after severe burn injury and its eventual association with fluid intakes. Retrospective study of prospectively collected data including patients with burns ≥ 20%BSA (body surface area) who stayed ≥ 24 h at the burn-intensive care unit (ICU). Predetermined data for the analysis of fluid and blood products administration and laboratory values were extracted from the computerized information system. Descriptive statistics, data as median. 167 patients included. The volumes of fluid resuscitation decreased over the first 10 days (median 6815 ml on day 1 decreasing to 4190 ml by day 10, p