Massive underrepresentation of Arabs in genomic studies of common disease

Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and...

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Veröffentlicht in:	Genome medicine 2023-11, Vol.15 (1), p.99-5, Article 99
Hauptverfasser:	Bhattacharya, Romit, Chen, NingNing, Shim, Injeong, Kuwahara, Hiroyuki, Gao, Xin, Alkuraya, Fowzan S, Fahed, Akl C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Arab Arab Americans Arab people Arabs - genetics Biobanks Cardiovascular disease Datasets Diabetes Diaspora Discrimination in medical care Diversity Genome Genome-wide association studies Genome-Wide Association Study Genomes Genomic Genomics Health care disparities Health disparities Humans Medical research Medicine, Experimental Middle East Polygenic score Population Prevalence studies (Epidemiology) Public health Type 2 diabetes Underrepresentation
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Zusammenfassung:	Arabs represent 5% of the world population and have a high prevalence of common disease, yet remain greatly underrepresented in genome-wide association studies, where only 1 in 600 individuals are Arab. We highlight the persistent and unaddressed underrepresentation of Arabs in genomic databases and discuss its impact on public health genomics and missed opportunities for biological discovery.
ISSN:	1756-994X 1756-994X
DOI:	10.1186/s13073-023-01254-8