Osteogenic Activity of Lupeol Isolated from Clinacanthus nutans Lindau: Activity and Mode of Action

Osteogenic Activity of Lupeol Isolated from Clinacanthus nutans Lindau: Activity and Mode of Action

Clinacanthus nutans Lindau has been traditionally used for healing of bone fragility, but the mechanism of actions has not been clarified yet. In this study, the bone regeneration activity of lupeol derived from C. nutans was assessed using an in vitro model of osteoblast cells MC3T3-E1. The finding...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of chemistry 2021-09, Vol.2021, p.1-8
Hauptverfasser: Nguyen, Minh T. H., Ngo, Quang V., Nguyen, Huyen T. T., Pham, Quan M., Dinh, Trang H., Nguyen, Huong T. T., V. Tinh, Nguyen, Nguyen, Phuong T. M.
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline phosphatase
Biomarkers
Biomedical materials
Chromatography
Differentiation
Ethylenediaminetetraacetic acid
Fragility
Genes
Healing
Herbal medicine
Medicinal plants
Medicine, Botanic
Medicine, Herbal
Mineralization
Osteoporosis
Phosphatases
Proteins
Regeneration (physiology)
Signaling
Solvents
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Clinacanthus nutans Lindau has been traditionally used for healing of bone fragility, but the mechanism of actions has not been clarified yet. In this study, the bone regeneration activity of lupeol derived from C. nutans was assessed using an in vitro model of osteoblast cells MC3T3-E1. The finding revealed that the compound was not significantly toxic to osteoblast cells at concentration of ≤40 μg/mL. Lupeol demonstrated the osteogenic activity through enhancement of alkaline phosphatase (ALP) of osteoblast cells up to 31.2%, 21%, and 12% at concentrations of 5, 10, and 20 µg/mL, respectively (p 
ISSN:2090-9063
2090-9071
DOI:10.1155/2021/6704999