Nanotechnology and flavonoids: Current research and future perspectives on cardiovascular health

[Display omitted] •Pioneering review of nanotechnology applications in enhancing flavonoid efficacy for cardiovascular health.•Comprehensive analysis of recent studies on nanocarrier systems for flavonoid delivery, including liposomes, nanoparticles, and nanoemulsions.•Insights into the mechanisms of flavonoids in regulating cardiovascular functions and preventing diseases.•Discussion of the challenges in clinical applications of nanoencapsulated flavonoids, including safety, dosage optimization, and regulatory compliance.•Exploration of future research directions, including scale-up production, long-term toxicity studies, and extensive clinical trials to validate flavonoid nanotherapeutics in cardiovascular health maintenance and disease treatment. The integration of nanotechnology and flavonoid research represents a novel approach to deliver and stabilize flavonoid, potent natural antioxidants present in various fruits and vegetables, renowned for their beneficial effects on cardiovascular function. This review provides an overview of the latest advancements nanotechnology to enhance flavonoid bioavailability, delivery, and efficacy. We examined various nanocarriers, including liposomes, nanoparticles, and nanoemulsions, that are utilized for encapsulating flavonoids. This encapsulation serves to protect flavonoids from degradation and enable their effective biodistribution in cardiovascular tissues. Recent research indicates that nanoencapsulated flavonoids improve therapeutic effets by lowering oxidative stress and inflammation; and improving lipid profiles in cardiovascular diseases. Moreover, we investigated the mechanism contributing to the cardiovascular advantages of flavonoids, including their ability to regulate endothelial function, blood pressure, and atherosclerosis prevention. Additionally, we analyzed challenges in translating these discoveries into clinical practice, such as ensuring safety, optimizing dosage, and addressing regulatory requirements. Future prospects include increasing production capacity, conducting extensive toxicity research over an extended period, and executing comprehensive clinical trials to confirm the efficacy of flavonoid based nanotherapeutics in maintaining cardiovascular health and managing related diseases. The integration of nanotechnology and flavonoid research represents a novel approach to deliver and stabilize flavonoids, potent natural antioxidants renowned for their cardiovascular benefits. This review