Intradermal tests with vasomotor agents in chronic non(infectious rhinitis

The aim of this prospective study was to examine the skin reactivity to four vasomotor agents in chronic, non-infectious rhinitis patients, and to determine whether non-allergic rhinitis (NAR) patients differ from allergic rhinitis (AR) patients. Seventy four patients with NAR and 44 with AR were subjected to intradermal testing with papaverin (5 mg/ml), metacholine (0.02, 0.2 and 2.0 mg/ml), histamine (0.01, 0.1, 1.0 and 10.0 ?g/ml) compound 48/80 (0.01, 0.1, 1.0 and 10.0 ?g/ml) and saline. It was found that the frequency of pathological skin reactivity to papaverin in the patients with NAR (25/74) was significantly greater (p=5.0?10-3) then in the patients with AR (4/44). No significant inter-group difference in skin reactivity to metacholine, histamine, compound 48/80 and saline was observed. The frequency of the total pathological skin reactivity to vasomotor agents, singly and in combinations, in patients with NAR (80%) was significantly greater (p=0.03) than in patients with AR (61%). These findings suggested that the pathological skin reactivity to papaverin, metacholine, histamine and compound 48/80 was a feature of chronic, non-infectious rhinitis patients and it was more frequently associated with non-allergic than with the allergic etiology of rhinitis. Cilj rada bio je da se utvrde karakteristike kutane reaktivnosti na papaverin, metaholin, histamin i supstanciju 48/80 kod bolesnika sa hronicnim, neinfektivnim rinitisom i da se ispita da li se bolesnici sa nealergijskim rinitisom (NAR) razlikuju od bolesnika sa alergijskim rinitisom (AR). U prospektivnu studiju bilo je ukljuceno 118 bolesnika sa hronicnim neinfektivnim rinitisom (74 bolesnika sa NAR i 44 bolesnika sa AR). Intradermalnim testovima ispitana je kutana reaktivnost na papaverin (5 mg/ml), metaholin (0,02, 0,2, 2,0 mg/ml), histamin (0,01, 0,1, 1,0, 10,0 ?g/ml), supstanciju 48/80 (0,01, 0,1, 1,0, 10,0 ?g/ml) i fizioloski rastvor Ucestalost patoloske kutane reaktivnosti na papaverin kod bolesnika sa NAR (25/74) bila je znacajno veca (p=0,005) nego kod bolesnika sa AR (4/44), dok medjusobna razlika u patoloskoj reaktivnosti na metaholin, histamin i supstanciju 48/80 nije bila znacajna. Kod 80% bolesnika sa NAR i 61% bolesnika sa AR nadjene su patoloske reakcije na jedan ili vise vazomotornih agensa, a razlika je bila znacajna (p=0,03). Rezultati ovog rada ukazuju na to da je patoloska kutana reaktivnost na papaverin, metaholin, histamin i supstanciju 48/80 karakteristika bolesnika sa hr