Relationship Between Fibroblast Growth Factor 19 and Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus

This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed...

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Veröffentlicht in:	Diabetes, metabolic syndrome and obesity metabolic syndrome and obesity, 2021-01, Vol.14, p.4715-4721
Hauptverfasser:	Chung, Jin Ook, Park, Seon-Young, Cho, Dong Hyeok, Chung, Dong Jin, Chung, Min Young
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Body mass index Cardiovascular disease Care and treatment Cholesterol Coronary vessels Diabetes Diabetic retinopathy Diabetics fibroblast growth factor 19 Fibroblast growth factors Fibroblasts Growth factors Heart failure Hyperglycemia Hypertension Insulin Medical research Medicine, Experimental Metabolism Original Research Pathogenesis Sample size Type 2 diabetes type 2 diabetes mellitus Variance analysis Vein & artery diseases
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Beschreibung
Zusammenfassung:	This study aimed to evaluate whether fibroblast growth factor 19 (FGF19) is associated with the risk of diabetic retinopathy in patients with type 2 diabetes mellitus (T2DM). A total of 357 patients with T2DM were investigated in this cross-sectional study. Logistic regression analysis was performed to assess the association between FGF19 level and diabetic retinopathy. Serum FGF19 level was significantly lower in patients with diabetic retinopathy in those without diabetic retinopathy. The multivariable analysis revealed a significant association between serum FGF19 level and diabetic retinopathy (odds ratio for every 1 standard deviation increase in logarithmic value = 0.69, 95% confidence interval 0.51-0.94, = 0.019). Serum FGF19 level was negatively associated with diabetic retinopathy in patients with T2DM.
ISSN:	1178-7007 1178-7007
DOI:	10.2147/DMSO.S339954