Distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock

Objective To explore the distribution of blood culture pathogens and clinical characteristics in children with acute leukemia complicated with septic shock. Methods Clinical data of 70 acute leukemia children complicated with septic shock who were positive for blood culture were retrospectively analyzed. The pathogenic findings and clinical characteristics of these cases were collected. Results Among 70 children， 44 （62.9%） cases were positive for blood culture. 33 Gram-negative bacteria （GNB）， 12 Gram-positive bacteria （GPB） and 2 fungi were cultured. The most common GNB was Pseudomonas aeruginosa （8/33， 24.2%）， followed by Escherichia coli （6/33， 18.2%）， Stenotrophomonas maltophilia （5/33， 15.2%） and Klebsiella pneumoniae （4/33， 12.1%）. GPB mainly consisted of Staphylococcus epidermidis， Staphylococcus aureus， Staphylococcus haemolyticus and Streptococcus retardans （2/12， 16.7% for each）. Multi-drug resistant organisms （MDRO） accounted for 48.9% （22/45）. Compared with GPB infections， the duration of antibio