The antifungal properties of terpenoids from the endophytic fungus Bipolaris eleusines

A series of terpenoids ( 1–17 ), comprising six new compounds designated bipolariterpenes A-F ( 1–6 ) and eleven recognized compounds ( 7–17 ), were isolated from the wheat culture of the potato endophytic fungus Bipolaris eleusines . Their structures and stereochemistry were clarified by HRESIMS, NMR, DP4 + probability analyses, and computations for electronic circular dichroism (ECD). All compounds are made up of six meroterpenoids, four sesterterpenes and seven sesquiterpenes. Among them, four sesterterpenes ( 4 , 5 , 10 , 11 ) were investigated for their antifungal, antibacterial and cytotoxic properties, and six meroterpenoids ( 1–3 , 7–9 ) were evaluated for their antifungal properties. The compounds 7 , 9 , and 10 had substantial antifungal activity against Epidermophyton floccosum at a concentration of 100 µM. No antibacterial and cytotoxic activities were observed. Graphical Abstract