Causal effects of gut microbiome on hypertension: a Mendelian randomization study

Previous observational studies have shown that there is an important relationship between gut microbiota and hypertension, we performed a two-sample Mendelian randomization analysis to examine whether the gut microbiota is causally related to hypertension in order to find a basis for potential diagnostic or intervention approaches for hypertension. We obtained significant single nucleotide polymorphisms related to gut microbiota and hypertension from publicly available genome-wide association studies for a two-sample Mendelian randomization study. A total of 18,340 individual genome-wide genotype data were included from 24 population-based cohorts. The inverse-variance weighted meta-analysis is the main analytical method for evaluating causal relationships, and the Mendelian randomization research results have been validated through a series of sensitivity analyses. The inverse-variance weighted analysis results indicated that phylum (OR:0.831, 95%CI: 0.710-0.972; = 0.021), family (OR:0.672, 95%CI: 0.496-0.911; = 0.01), family (OR:0.709, 95%CI:0.569-0.884, = 0.002), genus (OR: 0.991, 95%CI: 0.982-0.999, = 0.035), genus (OR:0.819, 95%CI:0.685-0.981; = 0.03), genus (OR:0.990, 95%CI:0.981-0.999; = 0.025), and genus (OR:0.988, 95%CI: 0.979-0.997; = 0.008) had protective causal effects on hypertension. The Family (OR:1.011, 95%CI:1.000-1.021, = 0.04), Genus (OR:1.375, 95%CI:1.096-1.653; = 0.025), Genus (OR:1.899, 95%CI:1.361-2.348; = 0.02), and Genus (OR:1.536, 95%CI:1.072-2.202; = 0.019) were associated with a higher risk of HTN. The reverse Mendelian randomization analysis results showed no reverse causal relationship between HTN and these bacterial taxa. Our Mendelian randomization analysis results indicate a potential causal relationship between these bacterial taxa and hypertension, providing a new perspective for the treatment and prevention of hypertension.