The Effect of Scrophularia striata Extracts on Wound Healing of Mice

Abstract Background & aim: Scrophularia striata extract has been traditionally used for wound healing. The aim of this study was to evaluate the effect of Scrophularia striata extract on wound healing on mice. Methods: In this experimental study, a number of 35 male mice (NMRI) weighing 25-30 g were divided into 5 equal groups. Two 6 mm circular wounds were punched on the back of the mice moreover they were treated for 3 weeks in separate cages. The first group wasconsidered as the control group and the other groups were treated with phenytoin ointment 1%, alcoholic extract, hydroalcoholic and aqueous 10% twice a day for 21 days respectively. The wounds were daily photographed by a digital camera and the wound area was calculated using Image J software. Data were analysed by Kruskal-Wallis and Mann-Whitney test. Results: The average healing duration in the control group, phenytoin and extracts, aqueous and alcoholic were 9.1 ± 3 6, 6.6± 1.9, 6.5 ± 1.7, 6.7 ± 1.8 and 6.1 ± 0.9 days respectively. The remaining scar size in these groups were 9.08 ± 1.83, 5.84 ± 1.20, 3.7 ± 0.62, 3.5 ± 0.74 and 2.81 ± 0.79 millimeters respectively. The average duration of scar healing and the remaining treatment groups were significantly different from controls (p