Distribution of quinolone resistance gene ( qnr ) in ESBL- producing Escherichia coli and Klebsiella spp. in Lomé, Togo

genes are known to confer a low-level resistance to fluoroquinolone in . They are often found on the same resistance plasmids as extended spectrum β-lactamase (ESBL) and constitute the most common antibiotic resistance mechanism. This study aimed to detect the presence of r genes in -producing and . From May 2013 to July 2015, 91 and 64 strains with phenotypic resistance to quinolone were collected from several specimens and analyzed for the detection of genes and the β-lactamase resistance genes ( , , ) using simplex and multiplex PCR. In the present study, 107 (69%; 61 and 46 ) of 155 bacterial strains tested were found harboring at least one gene consisting of 74 (47.74%) , 73 (47.10%) and 4 (2.58%) . Of the 107 strains encoding genes, 102, 96 and 52 carried , and type ESBL respectively. This study identified quinolone resistance ( ) gene in -producing and in Togo. These finding which suggest a possible resistance to quinolone are of high interest for better management of patients and control of antimicrobial resistance in Togo.