Polyglutamic Acid‐Based Elastic and Tough Adhesive Patch Promotes Tissue Regeneration through In Situ Macrophage Modulation

Adhesive patches are advanced but challenging alternatives to suture, especially in treating fragile internal organs. So far there is no suture‐free adhesive patch based on metabolizable poly(amino acid) materials with excellent mechanical strength as well as immunomodulation functionality. Here, a polyglutamic acid‐based elastic and tough adhesive patch modified by photosensitive groups on the surface to achieve robust light‐activated adhesion and sealing of flexible internal organs is explored. With the porous internal morphology and excellent biodegradability, the patches promote regeneration through a macrophage‐regulating microenvironment. Treated rabbits achieve rapid full‐thickness gastric regeneration with complete functional structure within 14 d, suggesting its robust tissue adhesion and repair‐promoting ability. An elastic and robust light‐controlled adhesive patch (LAP) is fabricated for suture‐free dynamic internal tissue adhesion. The adhesive patch plays a role in promoting tissue regeneration function beyond the simple wound sealing effect. Its appropriate degradation time and pro‐regenerative macrophage response generate a suitable immune microenvironment for in situ tissue repair and regeneration.