Liver and Pancreatic Toxicity of Endocrine-Disruptive Chemicals: Focus on Mitochondrial Dysfunction and Oxidative Stress

In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt vario...

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Veröffentlicht in:International journal of molecular sciences 2024-07, Vol.25 (13), p.7420
Hauptverfasser: Lința, Adina V, Lolescu, Bogdan M, Ilie, Cosmin A, Vlad, Mihaela, Blidișel, Alexandru, Sturza, Adrian, Borza, Claudia, Muntean, Danina M, Crețu, Octavian M
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Sprache:eng
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Zusammenfassung:In recent years, the worldwide epidemic of metabolic diseases, namely obesity, metabolic syndrome, diabetes and metabolic-associated fatty liver disease (MAFLD) has been strongly associated with constant exposure to endocrine-disruptive chemicals (EDCs), in particular, the ones able to disrupt various metabolic pathways. EDCs have a negative impact on several human tissues/systems, including metabolically active organs, such as the liver and pancreas. Among their deleterious effects, EDCs induce mitochondrial dysfunction and oxidative stress, which are also the major pathophysiological mechanisms underlying metabolic diseases. In this narrative review, we delve into the current literature on EDC toxicity effects on the liver and pancreatic tissues in terms of impaired mitochondrial function and redox homeostasis.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25137420