Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination - Case Report and Literature Review

Acute Liver Failure Caused by Secondary Hemophagocytic Lymphohistiocytosis After COVID-19 Vaccination - Case Report and Literature Review

Hemophagocytic lymphohistiocytosis (HLH) is a congenital or acquired hyperinflammatory syndrome, in some cases accompanied by acute liver failure. We present a case report of acute liver failure associated with HLH after COVID-19 vaccination and bring a literature review of the connection between HL...

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Veröffentlicht in:International medical case reports journal 2023-09, Vol.16, p.449-455
Hauptverfasser: Premec, Hrvoje, Živko, Matea, Mijić, Maja, Jelić-Puškarić, Biljana, Lalovac, Miloš, Filipec Kanižaj, Tajana, Sobočan, Nikola
Format: Artikel
Sprache:eng
Schlagworte:
acute liver failure
Case Report
Coronaviruses
covid-19 vaccine
Croatia
Enzymes
Health aspects
hemophagocytic lymphohistiocytosis
Liver failure
Metronidazole
Mortality
multisystem inflammatory syndrome
RNA
Transplantation of organs, tissues, etc
Vaccination
Virus diseases
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Zusammenfassung:Hemophagocytic lymphohistiocytosis (HLH) is a congenital or acquired hyperinflammatory syndrome, in some cases accompanied by acute liver failure. We present a case report of acute liver failure associated with HLH after COVID-19 vaccination and bring a literature review of the connection between HLH and COVID-19 vaccination. HLH has significant mortality rate, and liver transplantation is not a therapeutic option. Therefore, early recognition and timely conservative treatment are corner stones in reducing HLH-related morbidity and mortality.
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S417347