Versatile Flexible Graphene Multielectrode Arrays

Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocomp...

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Veröffentlicht in:	Biosensors (Basel) 2016-12, Vol.7 (1), p.1
Hauptverfasser:	Kireev, Dmitry, Seyock, Silke, Ernst, Mathis, Maybeck, Vanessa, Wolfrum, Bernhard, Offenhäusser, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biocompatibility Biosensing Techniques - instrumentation Biosensing Techniques - methods Cardiac muscle Cell Line cell-graphene interface Cells, Cultured Communication Dielectric Spectroscopy Electrical impedance extracellular recordings GMEA Graphene graphene electrodes Graphite Heart diseases Low noise Microelectrodes Myocytes, Cardiac - physiology Noise measurement Rats Sensor arrays Spectroscopy
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Beschreibung
Zusammenfassung:	Graphene is a promising material possessing features relevant to bioelectronics applications. Graphene microelectrodes (GMEAs), which are fabricated in a dense array on a flexible polyimide substrate, were investigated in this work for their performance via electrical impedance spectroscopy. Biocompatibility and suitability of the GMEAs for extracellular recordings were tested by measuring electrical activities from acute heart tissue and cardiac muscle cells. The recordings show encouraging signal-to-noise ratios of 65 ± 15 for heart tissue recordings and 20 ± 10 for HL-1 cells. Considering the low noise and excellent robustness of the devices, the sensor arrays are suitable for diverse and biologically relevant applications.
ISSN:	2079-6374 2079-6374
DOI:	10.3390/bios7010001