In vitro and in vivo antioxidant activity of a water-soluble polysaccharide from Dendrobium denneanum

The water-soluble crude polysaccharide (DDP) obtained from the aqueous extracts of the stem of Dendrobium denneanum through hot water extraction followed by ethanol precipitation, was found to have an average molecular weight (Mw) of about 484.7 kDa. Monosaccharide analysis revealed that DDP was com...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2011-02, Vol.16 (2), p.1579-1592
Hauptverfasser:	Luo, Aoxue, Ge, Zhongfu, Fan, Yijun, Luo, Aoshuang, Chun, Ze, He, Xingjin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant activity Antioxidants Antioxidants - chemistry Antioxidants - metabolism Benzothiazoles - chemistry Benzothiazoles - metabolism Dendrobium - anatomy & histology Dendrobium - chemistry Dendrobium denneanum Glucose Hydroxyl Radical - chemistry Hydroxyl Radical - metabolism Mice Molecular weight Monosaccharides - analysis Nuclear Magnetic Resonance, Biomolecular Plant Extracts - chemistry Plant Extracts - metabolism Plant Stems - chemistry polysaccharide Polysaccharides - chemistry Polysaccharides - metabolism Random Allocation Spectroscopy, Fourier Transform Infrared Sulfonic Acids - chemistry Sulfonic Acids - metabolism Superoxide Dismutase - metabolism Water - chemistry
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Zusammenfassung:	The water-soluble crude polysaccharide (DDP) obtained from the aqueous extracts of the stem of Dendrobium denneanum through hot water extraction followed by ethanol precipitation, was found to have an average molecular weight (Mw) of about 484.7 kDa. Monosaccharide analysis revealed that DDP was composed of arabinose, xylose, mannose, glucose and galactose in a molar ratio of 1.00:2.66:8.92:34.20:10.16. The investigation of antioxidant activity both in vitro and in vivo showed that DDP is a potential antioxidant.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules16021579