Heterogeneity in lung cancers by single‐cell DNA sequencing

Overall, cell numbers and Gini indices vary between subclones, illustrating CNV tumor heterogeneity in LUAD, LUSC, and SCLC (Figure 1 and Table S2). [...]hierarchical clustering of subclone CNVs revealed inter-patient similarities (Figures S4 and S5, Table S3 and Supporting Information Results). SV- plus CNV-based phylogenies match CNV-derived phylogenies, indicating pre-PCNE genome variations (Figures S11–S13). [...]diverse intra-tumor genetic alterations are evident across cohorts. [...]our findings reflect extensive subclone diversity in lung tumors concerning CNVs and cSVs.