The Dual Function of RhoGDI2 in Immunity and Cancer

RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is also present in a large array of other cell types. RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it c...

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Veröffentlicht in:International journal of molecular sciences 2023-02, Vol.24 (4), p.4015
Hauptverfasser: Tripathi, Mudrika, Colige, Alain, Deroanne, Christophe F
Format: Artikel
Sprache:eng
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Zusammenfassung:RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases. It is highly expressed in hematopoietic cells but is also present in a large array of other cell types. RhoGDI2 has been implicated in multiple human cancers and immunity regulation, where it can display a dual role. Despite its involvement in various biological processes, we still do not have a clear understanding of its mechanistic functions. This review sheds a light on the dual opposite role of RhoGDI2 in cancer, highlights its underappreciated role in immunity and proposes ways to explain its intricate regulatory functions.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24044015