Use of Ceftazidime-Avibactam for Suspected or Confirmed Carbapenem-Resistant Organisms in Children: A Retrospective Study

Background: The incidence of carbapenem-resistant organism (CRO) infections is increasing in children. However, pediatric-specific treatment strategies present unique challenges. Ceftazidime/avibactam is a [beta]-lactam/[beta]-lactamase inhibitor combination, showing adequate efficiency against CRO...

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Veröffentlicht in:	Infection and drug resistance 2023-09, Vol.16, p.5815-5824
Hauptverfasser:	Meng, Haiyang, Zhao, Yongmei, An, Qi, Zhu, Baoling, Cao, Zhe, Lu, Jingli
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial pneumonia Beta lactamases carbapenem-resistant organisms Ceftazidime ceftazidime-avibactam children China Escherichia coli Ethylenediaminetetraacetic acid Imipenem Mortality Original Research Pediatrics Pneumonia
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Zusammenfassung:	Background: The incidence of carbapenem-resistant organism (CRO) infections is increasing in children. However, pediatric-specific treatment strategies present unique challenges. Ceftazidime/avibactam is a [beta]-lactam/[beta]-lactamase inhibitor combination, showing adequate efficiency against CRO isolates. However, clinical data on the efficacy of ceftazidime/avibactam in children are still lacking. Methods: This was a retrospective study of children (aged
ISSN:	1178-6973 1178-6973
DOI:	10.2147/IDR.S426326