BrainDevo: Spatio-Temporal Gene Regulation Repository of Brain Development

Most of them are components of signaling networks encoding the production of transcription factors (TFs), cell adhesion proteins, cell surface receptor proteins and morphogens. [...]these genes function as master regulators by orchestrating other regulatory genes which regulate target/core genes involved in anatomical and physiological processes in the developing embryo. [...]these deviations are predominantly due to the mechanisms by which the toolkit genes precisely regulate the core genes' expression in space and time (Carroll, 2008). [...]single nucleotide polymorphisms (SNPs) in these regulatory regions can impact TF-DNA interactions and play a crucial role in regulating core gene expression. Dynamic Regulatory Event Miner (DREM) (Schulz et al., 2012), a unique approach, integrates disparate-omics data and time-series gene expression data (Ernst et al., 2007; Schulz et al., 2012, 2013) to identify target genes regulated by TFs. [...]contributing to the capture of time and region-specific gene regulation in developmental studies such as human brain development. There was a significant similarity of TFs involved in human brain development across all brain regions (see Figure 1). [...]we observed substantial gene regulatory activities during the prenatal stages of brain development.