Molecular Investigation of Beta Globin Gene Cluster Deletions in Anemic Patients Referred to the Genetic Laboratory of Amirkola Children Hospital (Iran)

Molecular Investigation of Beta Globin Gene Cluster Deletions in Anemic Patients Referred to the Genetic Laboratory of Amirkola Children Hospital (Iran)

BACKGROUND AND OBJECTIVE: Hereditary persistence of fetal hemoglobin (HPFH) and δβ-thalassemia are heterogeneous disorders characterized by elevated levels of fetal hemoglobin (Hb F). Deletional mutations are responsible for the disease and are not recognized by routine hematological tests. The aim...

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Veröffentlicht in:Majallah-i Dānishgāh-i ʻUlūm-i Pizishkī̄-i Bābul 2012-05, Vol.14 (3), p.13-18
Hauptverfasser: MR Ahmadi Fard, H Akhavan Niaki, H Mahmoodi Nesheli, A Banihashemi, M Azizi, N Mousavi, R Pourbagher, R Yousefi Kamangari
Format: Artikel
Sprache:eng
Schlagworte:
delta beta thalassemia
hemoglobin lepore
pcr
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Zusammenfassung:BACKGROUND AND OBJECTIVE: Hereditary persistence of fetal hemoglobin (HPFH) and δβ-thalassemia are heterogeneous disorders characterized by elevated levels of fetal hemoglobin (Hb F). Deletional mutations are responsible for the disease and are not recognized by routine hematological tests. The aim of this study was to perform a molecular characterization of beta globin gene cluster deletions in anemic patients referred to the genetic laboratory of Amirkola children hospital.METHODS: In this cross sectional study, thirty patients (14 females and 16 males) with mild microcytic hypochromic anemia with hematologic index (MCV
ISSN:1561-4107
2251-7170