Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Manic-Like Psychosis Associated with Elevated Trough Tacrolimus Blood Concentrations 17 Years after Kidney Transplant

Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated wit...

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Veröffentlicht in:Case reports in psychiatry 2013-01, Vol.2013 (2013), p.1-3
Hauptverfasser: Bersani, Giuseppe, Marino, Pietropaolo, Valeriani, Giuseppe, Cuoco, Valentina, Zitelli, Claudia, Melcore, Claudia, Bersani, Francesco Saverio
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Case Report
Colleges & universities
Consciousness
Delirium
Drug dosages
Hospitalization
Hospitals
Hypotheses
Insomnia
Medical treatment
Neurotoxicity
NMR
Nuclear magnetic resonance
Psychosis
Transplants & implants
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Zusammenfassung:Several neurological side effects induced by tacrolimus are described in the scientific literature, ranging from mild neurological symptoms to delirium and psychosis. We report the case of a 46-year-old man with no prior psychiatric history who suddenly manifested manic-like psychosis associated with elevated trough tacrolimus blood concentrations 17 years after kidney transplant. The use of antipsychotics may improve the severity of symptoms; but in order to obtain a complete remission, the reduction in the dose of tacrolimus, or its replacement with alternative immunosuppressant therapies, is recommended.
ISSN:2090-682X
2090-6838
DOI:10.1155/2013/926395