Oral Bacteria Dysbiosis in Patients with Linezolid-Induced Black Hairy Tongue: A Case Series

Linezolid-induced black hairy tongue is a self-limiting benign disease that is rare. Here, we report three patients who developed black hairy tongue after linezolid treatment. The severe dysbiosis of oral bacterial communities was observed in all these patients. Proteobacteria was the most prevalent...

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Veröffentlicht in:	Infection and drug resistance 2022-01, Vol.15, p.5449-5454
Hauptverfasser:	Shangguan, Yanwan, Ji, Zhongkang, Guo, Wanru, Hu, Wenjuan, Li, Xiaomeng, Xu, Kaijin
Format:	Artikel
Sprache:	eng
Schlagworte:	Abscesses Antibiotics Bacteria black-hairy tongue Care and treatment Case Series Complications and side effects Dysbacteriosis Edema Ethylenediaminetetraacetic acid Gram-positive bacteria Linezolid Magnetic resonance imaging Methicillin Metronidazole Microbiota microorganism metabolism Oral hygiene Patients Pemetrexed Physiological aspects Ribosomal RNA side-effect Staphylococcus infections Steroids Taxonomy Tetracycline Tetracyclines Tongue treatment Tuberculosis tuberculosis infection
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Zusammenfassung:	Linezolid-induced black hairy tongue is a self-limiting benign disease that is rare. Here, we report three patients who developed black hairy tongue after linezolid treatment. The severe dysbiosis of oral bacterial communities was observed in all these patients. Proteobacteria was the most prevalent phylum (over 90%) at the black tongue stage. Furthermore, the dramatic oral bacterial alteration took a long time to reverse after the BHT resolved.
ISSN:	1178-6973 1178-6973
DOI:	10.2147/IDR.S373266